Active Grants

ABI Development: A unified Galaxy-based platform for multi-omic data analysis and Informatics

09/01/2015 to 08/31/2018

The goal of this grant is to add capabilities to the Galaxy-P workflows that create custom, sample-specific protein databases from next generation mRNA sequencing data.

The Role of Sorcs1 and Sortilin in Diabetes Susceptibility

07/15/2015 to 06/30/2020

The goal of this grant is to elucidate the role of Sorcs1 and Sortilin in determining the intracellular fate of insulin.

Sequence-specific Capture for Discovering Protein-IncRNA Interactions in Prostate Cancer

04/01/2015 to 03/31/2018

The goal of this grant is to identify the proteins that are bound to specific IncRNA molecules, and then determine their relationship to the progression of prostate cancer and their potential as markers of the disease and its progression.

Intact Proteoform Identification and Quantification

04/01/2015 to 03/31/2019

The goal of this grant is to provide scientists with new tools to identify and quantify the protein variations at the whole protein level. This information will facilitate improved understanding of the functional relevance of genetic variations and lead to advances in the diagnosis and treatment of complex diseases.

Functional Characterization of Regulatory Sequence Variants in Complex Diseases

Texas Biomedical Research Institute/NIH/NHGRI
07/01/2014 to 06/30/2018

The goal of this project focuses on the development and optimization of three complementary techinologies that will improve our ability to efficiently characterize sequence variants uncovered in ongoing re-sequencing efforts of patients with both single gene and complex disorders.

Development and Applications of High Density RNA Arrays

07/01/2014 to 06/30/2018

The overall goals of this project are to refine and optimize a powerful new approach that we developed for the fabrication of high density RNA arrays and to demonstrate its utility in three important and interesting applications.